Expression of transforming growth factor-?_1 in the chronic pancreatitis tissue: Pathogenesis of chronic pancreatitis
- VernacularTitle:转化生长因子?_1在胰腺组织中的表达:慢性胰腺炎发病机制探讨
- Author:
Qilong CHEN
;
Guowei LI
;
Xiao CHEN
;
Renyong LIN
;
Xinjian XU
;
Hao WEN
- Publication Type:Journal Article
- Keywords:
PANCREATITIS/genet;
TRANSFORMING GROWTH FACTOR BETA;
GENE EXPRESSION
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect and significance of transforming growth factor-?_1(TGF-?_1), and TGF-?_1mRNA in the pathogenesis of chronic pancreatitis. Methods The expression and distribution of TGF-?_1, and TGF-?_1mRNA in the pancreatic tissue in different stage of the pathogenesis of chronic pancreatitis were studied with immunohistochemical SP staining, in situ hybridization,and reverse transcription-polymerase chain reaction on the canine model of chronic pancreatitis . Results The Expression of TGF-?_1 and TGF-?_1mRNA were found in fibrotic tissues, fibroblasts, macrophages and endothelial cells of blood vessels.The expression of TGF-?_1 and TGF-?_1mRNA were high and lasting in the pathogenesis of chronic pancreatitis. Conclusions High expression of TGF-?_1 is closely related to the fibroblast proliferating activity, extracellular matrix overdeposition and proceeding fibrosis of pancreas.
