Adult rat and human bone marrow mesenchymal stem cells differentiate into neurons with Musk's polypeptide
- VernacularTitle:麝香多肽体外诱导成年大鼠和人骨髓间充质干细胞定向分化为神经元的研究
- Author:
Qingzhong XIAO
;
Haowei LI
;
Guanmei WEN
;
Shaohua HUANG
;
Xiuming ZHANG
;
Yan LI
;
Shunong LI
- Publication Type:Journal Article
- Keywords:
Bone marrow;
Stem cells;
Neurons;
Musk polypeptide;
Cell differentiatio
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the differentiation from adult rat and human bone marrow mesenchymal stem cells (BMMSCs) into neuron with musk polypeptide (Mu-P).METHODS: Adult rat and human BMMSCs were induced with Mu-P.Neuron-specific enolase (NSE),neurofilament (NF),Nestin,glial fibrillary acidic protein (GFAP) were detected by immunohistochemistry.RESULTS: Simple methods with Mu-P induced adult rat and human BMMSCs exhibiting a neuronal phenotype,expressing Nestin at 3 hours to 5 hours,and expressing NE and NF at 5 hours to 7 days.But the neuron-like cells didn't express the glial astrocyte marker GFAP.CONCLUSION: Adult rat and human BMMSCs can be induced to differentiate into neurons with Mu-P.
