Effects of ?-MSH on biological activities of LPS
- VernacularTitle:?-MSH对脂多糖部分生物学活性的影响
- Author:
Bo CHEN
;
Yanping WANG
;
Daxiang LU
;
Liang YAN
;
Renbin QI
;
Suimei ZHANG
;
Yongmei FU
;
Shaobing CHENG
;
Chujie LI
- Publication Type:Journal Article
- Keywords:
MSH;
Lipopolysaccharides;
Macrophages;
Neutrophils;
Monocytes;
Inflammation
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The present study was undertaken to explore the effects of ?-MSH on partial biological activities of LPS. METHODS:Colorimetric method was used for the measurement of hydrogen peroxide(H_2O_2) production in mouse peritoneal macrophages, the apoptosis of polymorphonuclear leukocytes(PMNs) and the binding of LPS to monocytes were studied with flow cytometry. RESULTS: It was found that LPS strongly stimulated macrophages to release H_2O_2. When macrophages were cultured with ?-MSH in the presence of LPS, the H_2O_2 release was markedly suppressed (P0.05). In the presence of LPS, however, ?-MSH significantly promoted the apoptosis of PMNs (P
