Effects of nitric oxide on hepatic encephalopathy in cirrhotic rats induced by LPS
- VernacularTitle:NO在脂多糖诱发的肝硬化大鼠肝性脑病中的作用
- Author:
Jinchun LIU
;
Yanjiao LI
;
Dewu HAN
;
Chunhong NIU
;
Ruiling XU
;
Yuanchang ZHAO
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Lipopolysarrharides;
Liver cirrhosis;
Hepatic encephalopathy;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of nitric oxide (NO) on hepatic encephalopathy in cirrhotic rats induced by LPS. METHODS: The cirrhotic model of rats was established by complex pathogeny. Since the end of the 8 th week, the rats were intragastrically-infused with 0.9% salt, L-arginine(L-arg) and LNNA respectively for 2 weeks.The hepatic encephalopathy in cirrhotic rats were induced by 3 mg/kg LPS (ip) 4 hours before the rats were sacrificed. RESULTS: The normal behaviors and electroencephalograph were appeared in L-arg group. LNNA group showed hepatic encephalopathy. The content of NO-_2/NO-_3 of brain tissue was markedly higher in L-arg group than LNNA group(P
