The augmentative effect of inducible nitric oxide synthase on pulmonary fibrosis progression
- VernacularTitle:诱导型一氧化氮合酶对肺纤维化形成的促进作用
- Author:
Xiaoling CHEN
;
Yingmin LI
;
Shansheng HUANG
;
Dianhua WANG
;
Wenbin LI
- Publication Type:Journal Article
- Keywords:
Pulmonary fibrosis;
Nitric oxide synthase;
Immunohistochemistry;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the up-regulation of inducible nitric oxide synthase (iNOS) in lung of pulmonary fibrosis and its relationship with fibrosis. METHODS: The changes of amount of iNOS positive stain cells and type Ⅰ?Ⅲ collagen were examined on the day 7, 14 and 30 after intratracheal administration of bleomycin A_5. The contents of NO-_2/NO-_3 (nitrite/nitrate) in out-flowing pulmonary blood (OPB), hydroxyproline in lung and the histological changes were detected after iNOS was blocked by aminoguanidine (AG). RESULTS: (1) The number of iNOS-positive stain cells increased significantly in BLMA_5 7 d, 14 d and 30 d groups compared with that in control group (P
