Dynamic changes of the concentration of nitric oxide in ischemic myocardium and its mechanism
- VernacularTitle:心肌缺血时NO代谢的动态变化
- Author:
Weikang WU
;
Shiyun YANG
;
Xiaoai LIU
- Publication Type:Journal Article
- Keywords:
Myocardium;
Ischemia;
Nitric oxide;
Nitric-oxide synthase;
Gene expression
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The study was undertaken to explore the dynamic changes of the concentration of nitric oxide(NO) in ischemic myocardium and its mechanism.METHODS: In vivo myocardial ischemia of mice and in vitro perfused isolated heart of rat were used in the experiment. The effects of severity and time of ischemia on NO production, NOS activity and mRNA were examined, respectively. RESULTS: There was a considerable difference (P
