Effect of chronic hypoxia on [Ca~(2+)]_ i in pulmonary artery endothelial cells and smooth muscle cells under acute hypoxia
- VernacularTitle:慢性低氧对肺动脉内皮及平滑肌细胞急性低氧时胞浆游离钙变化的影响
- Author:
Chenhong LIU
;
Shengyuan LIU
;
Dixun WANG
- Publication Type:Journal Article
- Keywords:
Anoxia;
Muscle, smooth;
Endothelium;
Cells
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODS: Using Ca 2+ -sensitive fluorescent probe Fura-2,we measured the changes of _i in cultured rat pulmonary artery endothelial cells (PAEC) and porcine pulmonary artery smooth muscle cells (PASMC) from normoxic (NC group) or chronic hypoxic group (CH group) when they were exposed to acute hypoxia. RESULTS: The increase in _i in 6th passage of PASMC caused by acute hypoxia in CH group was significantly lower than that in the same passage of NC group (P
