Protective effect of compound Danshen dripping pills on isolated rat myocardium with anoxin/reoxygenation
- VernacularTitle:复方丹参滴丸对离体大鼠缺氧/复氧心肌的保护作用
- Author:
Yajun ZHAO
;
Congning SHI
;
Xiaoming WANG
;
Shijun ZHU
;
Liying MA
;
Xiaoshu JIANG
;
Yanping LOU
;
Lina WANG
;
Quanfeng LI
;
Changqing XU
- Publication Type:Journal Article
- Keywords:
Danshen;
Myocardium;
Anoxia;
Energy metabolism;
Myocardium ultrastructure;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The experiment was designed to study the effect of compound Danshen dripping pills (DSDP) on myocardium with anoxin/reoxygenation. METHODS: The myocardial anoxin/reoxygenation model was made in perfused isolated rat heart. DSDP and isosorbide dinitrate (ID) were given at the time of pre-perfusion and reperfusion, then HPLC and H-600 electron microscope were used to detect the change of high energy phosphate and the ultrastructure of myocardial cell. RESULTS: ① The contents of AMP, ADP, ATP and AN in myocardium in only anoxin/reoxygenation group were obviously lower than those in the control group (P0.05). ③ In the groups with ID, the contents of AMP, ADP, ATP and AN were distinctively lower than those in the control group (P
