Calcium/calmodulin-dependent protein kinase Ⅱ and its biologic function
- VernacularTitle:钙/钙调素依赖性蛋白激酶-Ⅱ及其生物学作用
- Author:
Quanbao WANG
;
Jianzhi WANG
- Publication Type:Journal Article
- Keywords:
Calmodulin;
Protein kinase-Ⅱ;
Learning;
Memory
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Ca 2+/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) is a member of a family of Ca 2+/calmodulin-regulated protein kinases which also includes Ca 2+/calmodulin-dependent protein kinases Ⅰ and Ⅲ, myosin light chain kinases and phosphorylase kinase. Unlike the other members of this family, CaMKⅡ is multifunctional protein kinase and distributes in a variety of tissues. It is especially abundant in neuronal system. In hippocampus, CaMKⅡ is about 2% of the total protein. Studies have shown that CaMKⅡ plays an important role in a variety of biological processes, such as regulation of gene transcription, synthesis of neurotransmitter, phosphorylation of cytoskeletonal protein, hippocampal learning and memory formation.
