Phenotype profiles and u-PA activity of bone marrow micrometastasis in breast cancer patients
- VernacularTitle:乳腺癌患者骨髓微转移细胞表型及骨髓血u-PA活性的研究
- Author:
Jie ZHANG
;
Kunwei SHEN
;
Jun WU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Bone marrow;
Neoplasm metastasis;
Phenotype;
u-PA activity
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the phenotype profiles of bone marrow micrometastatic tumor cells in patients with breast cancer. Methods Immunocytochemical staining was used to study the biologic markers of disseminated tumor cells, and U-PA activity of the plasma in the bone marrow was assayed in breast cancer patients.Results Judged by positive immunocytochemical staining of EMA and CK19, bone marrow micrometastasis was found in 30 out of 72 (41 67%) breast cancer patients. The primary tumor size (? 2=6 417, P=0 040) and p53 protein expression (? 2 =5 930, P=0 025) were significantly correlated with the incidence of micrometastasis. Disseminated tumor cells expressed low protein cyclinD1, p53,Ki-67, EGFR, and high protein p21. Tumor size and axillary lymph node status were found to be significantly correlated with the u-PA activity level. Conclusion Disseminated tumor cells in the bone marrow was in a status of low-cycling and low-proliferation.
