p27 protein expression in nodular goiter
- VernacularTitle:p27蛋白在结节性甲状腺肿中的表达研究
- Author:
Gang FENG
;
Yanping FU
;
Baohong XU
- Publication Type:Journal Article
- Keywords:
Goiter, nodular;
Thyroid neoplasms;
Immunohistochemistry;
p27 protein
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo measure p27 protein expression in nodular goiter and study the relationship between p27 protein expression and clinicpathologic factors.MethodsImmunohistochemical method-SP was used to detect expression of p27 protein in 42 cases of nodular goiter, 32 cases of normal thyroid tissues and 30 cases of thyroid cancer.ResultsThe positive expression rate of p27 protein was 52%?29% in nodular goiter, 87%?7 2% in normal thyroid tissue and 14%?12% in thyroid cancer. p27 protein expression in different thyroid tissues was significantly different (R 1,2=576, R 1,3=1?998, R 2,3=1?422, P
