Pharmacokinetic Analysis for Lactosaminated Recombination Human Growth Hormone and Recombination Human Growth Hormone by Radioimmunoassay
- VernacularTitle:放射免疫法研究乳糖基重组人生长激素和重组人生长激素的药代动力学
- Author:
Zelian CHEN
- Publication Type:Journal Article
- Keywords:
lactosaminated recombination human growth hormone;
recombination human growth hormone;
pharmacokinetics;
radioimmunoassay
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacokinetics of L-rhGH and rhGH in mice.METHODS:The concertrations of L-rhGH and rhGH in plasma and liver were measured by radioimmunoassay.RESULTS:After intravenous injection,there were significant differences between L-rhGH and rhGH in pharmacokinetic parameters.The Cmax of L-rhGH in the liver was higher than that of rhGH but the T1/2 of L-rhGH was only 17.9% of T1/2 of rhGH;the Cmax of L-rhGH in plasma was lower than that of rhGH and the T1/2 was shorter.CONCLUSION:L-rhGH reveals the pharmacokinetic characteristics which fits in with the physiology of human body.
