Study on the Preparation and in Vitro Dissolubility of Ofloxacin Hollow Suppository
- VernacularTitle:氧氟沙星中空栓的研制及体外溶出度考察
- Author:
Li JING
;
Renjie ZENG
;
Weizhang SUN
;
Yunping JIANG
;
Yong WANG
- Publication Type:Journal Article
- Keywords:
ofloxacin;
hollow suppository;
the first order derivative spectorphotometry;
dissolubility
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare ofloxacin hollow suppository(OHS) and to observe its in vitro dissolubility.METHODS:OHS was prepared with PEG 6000,PEG 400 and Carbopol-940 as wase material and wax as retardant.The content of ofloxacin in OHS was determined with the first order derivative UV-spectrophotometry.RESULTS:The wax,as a retardant,could retard the release of drug.The in vitro dissolution of OHS revealed the first order dissolution pattern:K0～1=27.81/h,indicating a speedy effect,K2～6=5.94/h,indicating sustained-release effect.CONCLUSION:This preparation is feasible in technology and controllabe in quality.The preparation of OHS extends the kinds of dose-form of ofloxacin
