Experimental Study on Healing of the Mandibular Defect of Rabbit By L-Dopa
- VernacularTitle:左旋多巴促进兔下颌骨缺损愈合的实验研究
- Author:
Jianjun YU
;
Zhihua SHEN
;
Zhuofang LIU
- Publication Type:Journal Article
- Keywords:
Bone defect,mandible;
L-Dopa;
Bone morphology;
Animal model,rabbit
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The effect of oral L-Dopa on healing of the experimental mandibular defect of rabbits was studied.Method 52 rabbits were assigned randomly to experimental group and control group.After bone defect being made on mandible,rabbits had been given with L-Dopa in experimental group.Healing bone samples were adopted at 14,21,30,42,49 days after operation,observed x-ray and histological changes and calculated out the bone histomorphometric parameters.Results X-ray inspection indicated that bone defect of the experimental group had completed callus union from 30th day.But,a part of the defect of control group did not appear callus union radiologically.Histological examination had the same result.Bone histormorphometry examination exhibited that there was a significant difference between TBV of the experimental and the control group(P
