G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health.
- Author:
Mi Jin KIM
1
;
Tae Hee KIM
;
Hae Hyeog LEE
Author Information
- Publication Type:Review
- Keywords: Estradiol; Estrogens; Genomics; GTP-binding proteins
- MeSH: DNA; Estradiol; Estrogens*; Female; Genomics; GTP-Binding Proteins*; Humans; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Transcription Factors; Women's Health*
- From:Journal of Menopausal Medicine 2015;21(2):79-81
- CountryRepublic of Korea
- Language:English
- Abstract: Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism.
