Effect of nitric oxide on liver ischemic precondition in rats
- VernacularTitle:一氧化氮在大鼠肝缺血预处理中的作用
- Author:
Yongqiang ZHAN
;
Xinsheng LU
;
Zhiming WANG
;
Yixiong LI
;
Guohuang HU
;
Qinghua ZENG
- Publication Type:Journal Article
- Keywords:
NITRIC OXIDE/pharmacol;
LIVER/blood surply;
REPERFUSION INJURY
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of nitiric oxide (NO) in the liver ischemic precondition (IP) in rats. Methods 131 rats were randomly assigned to ischemia/reperfusion (I/R)group, IP group and sham-operation(S) group. The plasma NO, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the pathological change of liver and rat mortality were observed at 2 hours, 24 hours and 1 week after operation. Results (1) The plasma NO level grew soon after operation in group IP, and was significantly higher than that in group S in all three time points (P0.05), and higher at 1 week (P
