Establishment of a canine model of fulminate hepatic failure
- VernacularTitle:犬暴发性肝功能衰竭模型的建立
- Author:
Wenhai XUAN
;
Yize HU
;
Heping PENG
;
Zhongchu HUANG
- Publication Type:Journal Article
- Keywords:
HEPATIC FAILURE,ACUTE;
DISEASE MODELS,ANIMAL
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a canine model of fulminate hepatic failure ( FHF) and study the treatment of FHF by partial orthotopic liver transplatation(POLT).Methods Carbon tetrachloride (CCL4) mixed with the same amount of peanut oil in the dosage of 0.9 ml per kilogram of body weight was injected intraperitoneally to canines. ALT,tolal bilirubine(TB), PT, NH 4,and blood suger(BG) were monitored. The pathological changes were observed when the canine died,remain alived animal were killed on 7th day and 14th day respectively. EEG was performed on 3rd day after the model eslablished. Results After CCl 4 was injected, the canine showed progressive hepatic failure, ALT, TB and NH rose persistantly, PT prolonged, and BG decreased (P
