Autosomal Translocation Patient Who Experienced Premature Menopause: A Case Report.
10.6118/jmm.2015.21.2.112
- Author:
Tae Hee KIM
1
;
Yesol KIM
;
Do Won JEONG
;
Eun Gyeong LEE
;
Dong Su JEON
;
Jun Mo KIM
Author Information
1. Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea. heeobgy@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Autosomal translocation;
Premature menopause;
Premature Ovarian Failure
- MeSH:
Female;
Gonads;
Hand;
Humans;
Menopause;
Menopause, Premature*;
Menstruation;
Oocytes;
Primary Ovarian Insufficiency;
X Chromosome
- From:Journal of Menopausal Medicine
2015;21(2):112-114
- CountryRepublic of Korea
- Language:English
-
Abstract:
Premature ovarian failure (POF) is a condition in which the ovarian functions of hormone production and oocyte development become impaired before the typical age for menopause. POF and early menopause are present in a broad spectrum of gonad dysgenesis, from a complete cessation of ovarian function to an intermittent follicle maturation failure. Actually POF has been identified as a genetic entity (especially chromosome X), but data on genetic factors of premature menopause are limited. Until now, several cases revealed that inactivation of X chromosomes has an effect on ages of premature menopause and females with balanced or unbalanced X-autosome translocations can have several reproductive problems. On the other hand, there have been a few data that was caused by autosome-autosome translocation can lead. Therefore we report a relevant case of POF with translocation between chromosomes 1 and 4. She had her first menstrual period at the age of 12, and after 7 years she stopped menstruation. Chromosomal analysis showed 46, XX, t (1;4) (p22.3;q31.3). While evaluating this rare case, we could review various causes (especially genetic factors) of POF. To remind clinicians about this disease, we report a case of POF caused by autosome-autosome translocation with a literature review.
