Expression of heme oxygenase-1 mRNA in portal hypertension rats
- VernacularTitle:门静脉高压大鼠血红素氧化酶-1mRNA的表达
- Author:
Li ZHANG
;
Jiadong HUANG
;
Zhen YANG
;
Jian WANG
;
Baoju WANG
;
Congyun FANG
- Publication Type:Journal Article
- Keywords:
HYPERTENSION,PORTAL;
HEME OXYGENASE;
DISEASE MODELS,ANIMAL
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between portal hypertension(PHT) and heme oxygenase-1(HO-1)mRNA expression in rats.Method An animal model of PHT induced by partial portal vein constriction was established to detect the expression of HO-1mRNA in the liver,spleen, and splenic vein of rats by situ hybridization method. Result HO-1mRNA was not detected in the liver, spleen, and splenic vein in the control group. In PHT rats, HO-1mRNA was not detected in the liver;but in the spleen,the expression of HO-1mRNA was 83.3%;in the splenic vein,the expression was 55.6%. Conclusions The PHT rat is in stress condition.The expression of HO-1mRNA in the spleen and splenic vein of PHT ratsare increased and the metabolic product of HO-1 may exacerbate the PHT.
