The genetic susceptibility of HLA-DRB1 alleles in esophageal neoplasm of Hubei Han Chinese
- VernacularTitle:HLA-DRB1等位基因多态性与食管癌遗传易感性研究
- Author:
Jun LIN
;
Jie SUN
;
Yan ZHOU
;
Xing HUANG
;
Ping XIONG
;
Yaping WANG
;
Changshen DENG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
HAL-DR antigens;
Polymerase chain reaction;
Genetics
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal neoplasm in Hubei Han Chinese. METHODS: HLA-DRB1 gene polymorphism in 42 patients with esophageal neoplasm and 136 normal control subjects was studied by PCR and sequence. RESULTS: Allele frequency of HLA-DRB1 *0901 allele was significantly higher in esophageal cancer patients than those in normal controls (0 2500 vs 0 1397,P =0 028; the odds ratio 2 053; etiologic fraction 0 1282).There were no association between the rested HLA-DRB1 alleles with patients. CONCLUSION: Individuals carrying HLA-DRB1 *0901 may be susceptible to esophagealo carcinoma, its nucleotide sepuence approachs to the corresponded allele sequence(exon 2)published in GenBank.
