Effects of Radix Angelicae Sinensis on changes of IL-6, TNF-? and bFGF in renal ischemia/reperfusion injury in rabbits
- VernacularTitle:兔肾缺血再灌注损伤时TNF-?、IL-6和bFGF的变化及当归的影响
- Author:
Lihua LI
;
Lisha WU
;
Chunling ZHAO
;
Xiaoyu XU
;
Yuchuan WU
;
Haiying LIN
;
Xianhua LI
;
Dabin LI
- Publication Type:Journal Article
- Keywords:
Radix Angelicae Sinensis;
Kidney ischemia;
Reperfusion injury;
Tumor necrosis factor;
Interleukin-6;
Fibroblast growth factor, basic
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To determine the effect of Radix Angelicae Sinensis(RAS) on renal ischemia/reperfusion injury in rabbits and to explore its mechanism. METHODS: Twenty-five rabbits were divided randomly into the sham operated group(Control group), renal ischemia/reperfusion injury group(IR group) and RAS+IR group. At the time point of reperfusion 48 h after renal ischemia 1 h, the renal tissue were observed by electron-microscope and the contents of creatinine(Cr) in serum, tumor necrosis factor-?(TNF-?), interleukin-6(IL-6)and basic fibroblast growth factor(bFGF) in the renal tissue were measured. RESULTS: A remarkably degenerative changes in renal tissue were showed under electronmicroscope in IR group , but the changes in RAS+IR group were slight . The contents of Cr, TNF-? and IL-6 in IR group were higher than those in Control group, these parameters in RAS+IR group were lower than those in IR group, the difference between these groups was significant ( P
