Inhibition of in vitro and in vivo granulomatous responses surrounding schistosome eggs by administration of Angelicae Sinensis
- VernacularTitle:当归对体内外血吸虫卵肉芽肿反应抑制作用的实验研究
- Author:
Keming XIE
;
Songguang JU
;
Yongping GU
;
Yumin HU
- Publication Type:Journal Article
- Keywords:
Angelicae Sinensis;
Granuloma;
Schistosoma, Japonicum
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To find out whether traditional Chinese medicine Angelicae Sinensis has direct suppressive effect on schistosome egg-induced granulomatous response. METHODS: The lung model of granuloma response was established by injecting living eggs of Schistosoma japonicum into the tail veins of eggs-sensitized mice then the preparation of Angelicae Sinensis were given intraperitoneally once a day for ten days. In vitro model of granulomatous reaction was set up by incubating dry schistosome eggs together with those splenocytes isolated from schistosome infected-mice or from the mice with pulmonary granuloma formation. Different doses of the preparation was, in the need of experiment, added to culture fluid. The sizes of granulomas formed surrounding single egg in lungs or the intensity of in vitro granulomatous responses were measured and observed. RESULTS: The average diameter of pulmonary granulomas in administered group was significantly smaller than that of the control ( P
