Change of central noradrenergic system in Alzheimer's disease
- VernacularTitle:Alzheimer病中枢肾上腺素能系统的变化
- Author:
Yaochun WANG
;
Zidong WANG
;
Sichun HE
;
Hui ZHENG
;
Lili ZHOU
- Publication Type:Journal Article
- Keywords:
Norepinephrine;
Alzheimer's disease;
Drugtherapy
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The abnormality of the central noradrenergic system in Alzheimer's disease has two cases: decrease or increase. The former is easy to be understood, because it is resulted from the outstanding forfeit of the noradrenergic neurons in the nucleus locus ceruleus (nLC); but the noradrenalin concentration does not change and enen increase, it seems to disagree with the loss of the noradrenergic neurons in the nLC. This article put emphasis on it, enumerated the related evidence and analyzed the possible causes. At present time, the drugs to increase noradrenalin is used mostly in clinic. This paper summarized it and put forth our own opinions.
