Protection of Lazaroid U-74389G pretreatment against graft warm ischemia reperfusion injury in rat liver transplantation from non-heart-beating donors
- VernacularTitle:Lazaroid U-74389G预处理对大鼠心脏停搏供体肝移植缺血再灌注损伤的保护作用
- Author:
Jiqi YAN
;
Hongwei LI
;
Mingjun ZHANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Reperfusion injury;
Transplantation conditioning
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the protective role of Lazaroid U 74389G pretreatment against graft warm ischemia reperfusion injury of rat liver transplantation from non heart beating donors.MethodsRat liver transplantation was carried out in 4 groups (N 45, N 60, tN 45 and tN 60), according to pretreatment with U 74389 G or not, and the non heart beating time of 45 or 60 minutes before donor liver was harvested.Survival rates, liver functions, MDA values and graft pathologies were compared between the groups.ResultsThe one week survival rates of group N 45, N 60, tN 45 and tN 60 were 25%(2/8), 0(0/8), 58%(7/12) and 33%(4/12) respectively.U 74389G pretreatment not only significantly increased survival rate of rat liver transplantation from non heart beating donors, but also improved liver functions and graft pathologies, as well as decreased MDA expression.Conclusions U 74389G pretreatment could attenuate ischemia reperfusion injury on donor livers and increase the survival rates in rat liver transplantation from non heart beating donors.
