The effect of integrin ?v subunit on the angiogenesis, invasiveness and metastasis of hepatocellular carcinoma
- VernacularTitle:整合素?v亚基对肝细胞性肝癌血管生成、侵袭转移的影响
- Author:
Heli LIU
;
Lianyue YANG
;
Gengwen HUANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Neovascularization, pathologic
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of integrin ?v subunit(?v) in hepatocellular carcinoma(HCC )and its effect. Methods With the method of immunohistochemistry, specimens from 43 HCC patients and 6 control patients were studied. The relationship between the ?v expression and pathological features,microvessel density(MVD) was evaluated.Results The difference of the expression of ?v in tumor cells between HCC with satellite lesions and without it was significant(H=9 008, P =0 003).The MVD of HCC with positive and negative expression of ?v in endothelia was 151?54 and 115?39 respectively,difference of which was significant( t =2 503, P =0 016).Conclusions Integrin ?v subunit may play an important role in the angiogenesis, invasiveness and metastasis of hepatocellular carcinoma.
