Experimental Study of Anti-hepatofibrotic Action of 18?-glycyrrhizic Acid in Rats
- VernacularTitle:18?-甘草酸抗大鼠肝纤维化实验研究
- Author:
Jing TIAN
;
Jian LU
- Publication Type:Journal Article
- Keywords:
glycyrrhizic acid;
gamma interferon;
anti-hepatofibrosis;
rat
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the anti-hepatofibrotic action of 18?-glycyrrhizic acid(18?-GL) and gamma interferon (IFN-?) in rats METHODS:The rat model of liver fibrosis was induced by dimethyl nitrosamine(DMN),18?-GL or IFN-? was administrated before and 5 weeks after giving DMN,to prevent and treat liver fibrosis The pathological changes and degree of fibrosis in the liver were observed and compared with that of DMN control group RESUTLS:Compared to DMN control group,the collagen deposition in both 18?-GL and INF-? groups was significantly slight in degree(P
