Determination of Methyl Hydroxybenzoate and Ethyl Hydroxybenzoate in Three Oral Liquid Preparations
- VernacularTitle:3种内服液体制剂中羟苯甲酯和羟苯乙酯的含量测定
- Author:
Quangang ZHU
;
Jinhong HU
;
Huajun SUN
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
methyl hydroxybenzoate;
ethyl hydroxybenzoate;
RP-HPLC
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish the RP-HPLC method for determination of methyl hydroxybenzoate and ethyl hydroxybenzoate in oral liquid preparations METHODS:The Nova-Park C18 column(3 9mm?150mm,5?m)was used The mobile phase consisted of acetonitrile-water(25∶75)at a flow rate of 1ml/min,the detection wavelength was set at 254nm and the sensitivity was set at 0 01 AUFS RESULTS:The linear ranges of methyl hydroxybenzoate and ethyl hydroxybenzoate were 0 4 412～13 2 360?g/ml(r=0 9 999) and 0 6 672～20 0 160?g/ml(r=0 9 998)respectively CONCLUSION:The method is simple,rapid and accurate It can be used to detect antiseptics in hospital preparations
