Study on the Level of Interleukin-6 mRNA of Placentae and Amnion in Severe Pregnancy-Induced Hypertension
- VernacularTitle:重度妊娠高血压综合征患者胎盘与羊膜IL-6 mRNA水平的研究
- Author:
Jingyin WANG
;
Xiaoru YI
;
Hong GAO
- Publication Type:Journal Article
- Keywords:
Interleukin-6;
Pregnancy complications, cardiovascular;
Hypertension;
Fetal growth retardation
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immune changes of interleukin-6(IL-6) of placentae and amnion in severe pregnancy-induced hypertension(PIH) and fetal growth retardation(FGR). Methods Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect IL-6 mRNA levls of placentae and amnion. Results The level of IL-6 mRNA in placentae and amnion in severe PIH group (0.71?0.07,0.81?0.02) are significantly lower than those in normal group(P0.05). Conclusions IL-6 is involved in the immune injury in severe PIH. The decreased levels of IL-6 in placentae and amnion may be the cause of fetal growth retardation
