Expression of Endothelin-1 and Endothelial Nitric Oxide Synthase Gene in Placental Villus in Preeclampsia
- VernacularTitle:妊娠高血压综合征患者胎盘绒毛组织内皮素1和内皮型一氧化氮合成酶的基因表达及其脐动脉血流变化
- Author:
Xiuqin TONG
;
Shilan LI
;
Yangyu ZHAO
- Publication Type:Journal Article
- Keywords:
Hypertension;
Pregnancy complications, cardiovascular;
Endotnelin-1;
Nitric-oxide synthase;
Chorionic villi;
Umbilical arteries;
Blood flow velocity
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of endothelin-1(ET-1) and endothelial nitric oxide synthase(eNOS) mRNA in the villus of pre-eclampsia and the effect of the ET-1 and eNOS on umbilical artery flow velocity wareforms. Methods Dot blotting, DIG-labeled human ET-1 and eNOS cDNA probes were used to examine the expression of the ET-1 and eNOS gene in the placental villus tissues of women with normal gestation and pre-eclampsia. Leica QWIN image disposal and analysis system were used to assess the mean OD of every dot. Colour doppler was used to examine the umbilical artery flow the day before childbirth. Results The level of ET-1 mRNA in placental villus was significantly higher in pre-eclampsia group than the normal group(0.43?0.03 versus 0.23?0.44,P
