Study on Relationship between Lipid Perioxidation and the Level of Serum Estriol and Expression of the Estrogen Receptors on Placentae in Intrahepatic Cholestasis of Pregnancy
- VernacularTitle:妊娠肝内胆汁淤积症患者脂质过氧化作用的变化与雌激素水平及受体的关系
- Author:
Dongmei WANG
;
Xiaolin LA
;
Jie CHEN
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
Cholestasis, intrahepatic;
Estrogens;
Receptors, estrogen;
Lipid peroxidation
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the changes of serum malondialdehyde(MDA),superoxidation dismutase (SOD) and the level of serum-estriol (E 3), ?-hCG, and expression of estrogen receptors(ER), HCG on placenta of intrahepatic cholestasis of pregnancy(ICP). Methods Thirty-three women with ICP and thirty normal pregnant women were enrolled in study. All elbow vein blood were drawn within half an hour before delivery. The level of SOD, MDA, E 3 and?-hCG were detected. Twenty cases of ICP group and control group were selected randomly and placental tissues were measured by using immunohistochemical method to assess the level of ER and hCG. Results The level of MDA and free E 3 in ICP group were [(6.4?2.1) mol/L],and were [(19?9 ng/ml)] higher than that in control group [(5.2?1.4 mol/L)], and [(14?6 ng/ml)] (P
