Expression of hepatocyte growth factor receptor in human epiretinal membranes and RPE cells
- VernacularTitle:肝细胞生长因子受体在视网膜前膜及培养的人视网膜色素上皮细胞中的表达
- Author:
Ling HUANG
;
Yannian HUI
;
Lili WANG
- Publication Type:Journal Article
- Keywords:
Vitreoretinopathy,proliferative;
Pigment epithelium of eye;
Proto oncogene protein c met;
Immunohistochemistry
- From:
Chinese Journal of Ocular Fundus Diseases
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of hepatocyte growth factor receptor (HGFR) in epiretinal membranes (ERM) of eyes with proliferative vitreoretinopathy (PVR) and cultured retinal pigent epithelium (RPE) cells. Methods Fifteen human epiretinal membranes were obtained from eyes undergone vitrectomy for rhegmatogenous retinal detachment complicated with PVR and observed by immunohistochemical examination to study the expression of HGFR. Using the immunohistochemical technique to evaluate the expression of HGFR in cultured RPE cells. Results In 6 membranes of PVR grade C, HGFR were expressed in 5/6, and 7 cases were detected in 9 membranes of PVR grade D.RPE cells express readily detectable levels of HGFR. Conclusion The findings indicate that HGF might be involved in the formation of epiretinal membranes in PVR.
