Effects of Radix Salviae Miltiorrhizae on the proliferation of vascular smooth muscle cells induced by plateletderived growth factor</span>
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<ul class="info">
<li><span class="info_l">VernacularTitle:</span><span class="info_r">丹参对血小板源生长因子刺激血管平滑肌细胞增生的影响</span></li>
<li><span class="info_l">Author:</span>
<span class="info_r" style="margin-left:-4px;">
Xiaogan MA
;
De SHI
<br>
<div style="display:none" id="affContent">
</div>
</span>
</li>
<li><span class="info_l">Publication Type:</span><span class="info_r">Journal Article</span></li>
<li><span class="info_l">Keywords:</span>
<span class="info_r" style="margin-left:-4px;">
RADIXSALVIAE MILTIORRHIZAE/pharmaco;
PLATELETPERIVED GROWTH FACTOR;
VASCULAR SMOOTH MUSCLE CELLS
</span>
</li>
<li><span class="info_l">From:</span><span class="info_r">
<a target="_blank" href="http://www.zpwz.net" class="websiteLink">Chinese Journal of General Surgery</a>
2001;0(08):-
</span>
</li>
<li><span class="info_l">Country</span><span class="info_r">China</span></li>
<li class="mb_30" style="margin-bottom:0px"><span class="info_l">Language:</span><span class="info_r">Chinese</span></li>
<li>
<span class="info_l">Abstract:</span>
<span class="info_r" style="margin-left: -4px;">
<b></b>ObjectiveTo determine the effects of Radix Salviae Miltiorrhizae (RSM) on the proliferation of vascular smooth muscle cells(SMC) induced by plateletderived growth factor(PDGF).MethodsRat arterial SMC cultured in vitro were divided into the control group, RSM group (subdivided into 3 concentration groups:2.0mg/ml, 0.4mg/ml and 0.08mg/ml),PDGF group(10ng/ml) and PDGF(10ng/ml) plus RSM (the 3 concentrations the as the same as above) group. The number of SMC and 3HTdR incorporation of SMC were measured. Results PDGF induced the increases of the number of SMC and 3HTdR incorporation of SMC significantly, which were as 3fold and 2.5fold as those of the basic situation respectively. RSM,which was dosedependent, inhibited the increase of the number of SMC and 3HTdR incorporation of SMC in the basic and PDGF stimulated situations . ConclusionsRSM may inhibit SMC proliferation in the basic and PDGF stimulated situations.
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