Role of phosphoinositide pathway in the formation of cardiac hypertrophy induced by pressure overload in rats
- VernacularTitle:心肌肥厚形成过程中肌醇磷脂途径的作用
- Author:
Xiaojian SUN
;
Yuanwei HUANG
;
Shenjiang HU
;
Yanke SHI
;
Jianhon LUO
- Publication Type:Journal Article
- Keywords:
Hypertrophy,left ventricular;
Signal transduction;
Inositol 1,4,5-triphosphate
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of phosphoinositide pathway in the formation of pressure-overload cardiac hypertrophy. METHODS: Cardiac hypertrophy was induced in male Sprague-Dawley rats with coarctation of abdominal aorta, whole heart weight/body weight ratio was tested after 10 or 30 days of operation. Content of G?q/11 protein in left ventricle was detected by immunoblot analysis and concentration of IP 3 was measured by radioimmunoassay. RESULTS: At 10 and 30 days, whole heart weight/body weight ratio of coarctation aorta (CA) group was higher than that of sham-operated (SO) rats ( P 0.05). At 10 days, the level of IP 3 significantly increased in left ventricle of CA rats compared with the control animals ( P
