Nucleus tractus solitarius participates in regulation of paraventricular nucleus vasopressinergic neurons on gastric ischemia-reperfusion injury in rats
- VernacularTitle:孤束核参与室旁核加压素能神经元对大鼠胃缺血-再灌注损伤的调控作用
- Author:
Yongmei ZHANG
;
Jianfu ZHANG
;
Changdong YAN
;
Xiuping ZHOU
;
Youjian QI
- Publication Type:Journal Article
- Keywords:
Paraventricular hypothalamic nucleus;
Reperfusion injury;
Argipressin
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of the nucleus tractus solitarius (NTS) in the regulation of paraventricular nucleus (PVN) AVP-ergic neurons on gastric ischemia- reperfusion injury (GI-RI). METHODS: Male SD rats were used in experiments. The celiac artery were clamped for 30 min and reperfused 1 h by removal of the clamp to obtain the ischemia-reperfusion state. The mechanism was analysed with nucleus electrical stimulation, electrolytic lesion and nucleus microinjection technique. RESULTS: Microinjection of arginine-vasopressin (AVP) into PVN obviously attenuated the GI-RI and dose-dependent effects were observed ( r= -0.477, P
