Effects of norepinephrine preconditioning and ischemic preconditioning on apoptosis and Bcl-2, Bax expression in rat myocardial cells during myocardial ischemic reperfusion
- VernacularTitle:去甲肾上腺素和缺血预处理对大鼠缺血再灌注心肌细胞凋亡、Bcl-2、Bax蛋白表达的影响
- Author:
Fangzhou CHENG
;
Guohua TANG
;
Gengshan LI
;
Xiqiu YU
;
Yuanzhong LI
;
Xinhua HE
;
Cuiyu BAO
;
Yu ZHOU
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning, myocardial;
Reperfusion;
Apoptosis;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of norepinephrine preconditioning(NE-P) and ischemic preconditioning (IP)on apoptosis and Bcl-2, Bax expression in rat myocardial cells in myocardial ischemic reperfusion (I/R). METHODS: The model of rat ischemic-reperfusion was used to conduct NE-preconditioning. Apoptotic myocytes were detected with TUNEL. Bcl-2, Bax expression were detected with immunohistochemistry. RESULTS: The rate of apoptosis cells in I/R group was higher, the rate of apoptosis cells in NE-P group and IP was lower significantly than that in I/R group( P0.05). CONCLUSION: NE-P reduced myocyte apoptosis by I/R in rats; The expression of Bcl-2 ,Bax genes played an important role in myocardial apoptosis.
