Effect of Jiere Xingshen Injection on cAMP, IL-1_? content in hypothalamus of ET febrile rabbits
- VernacularTitle:解热醒神注射液对内毒素性发热家兔下丘脑cAMP、IL-1_?含量的影响
- Author:
Danhui ZHANG
;
Yufeng JIANG
;
Qifu HUANG
;
Xu JIA
;
Jing YAN
;
Xuey LU
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Fever;
Adenosine cyclic monophosphate;
Interleukin-1;
Hypothalamus
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The effects of Jiere Xingshen(JRXS) Injection on cAMP, IL-1 ? content in hypothalamus (HP) of endotoxin(ET)-induced feverish rabbits were studied. METHODS: The ET-induced fever model was established in rabbits and the cAMP content in hypothalamus (HP) and csf, IL-1 ? content in HP were determined by radioimmunoassay following intravenous infusion of JRXS. RESULTS: In ET group, the ?T [(0 40?0 11)℃], TRI 1(1 78?0 79), cAMP content in HP [(2 90?0 40) nmol/g], cAMP content in csf [(32 10?4 51) nmol/L)], IL-1 ? content in HP[(6 08?0 79) ng/g] were higher than that of NS and JRXS+ET group ( P
