Roles of resident cells and infiltrating cells in renal tubulointerstitial injuries
- VernacularTitle:肾脏固有细胞和浸润细胞在肾小管间质病变中的作用
- Author:
Li YANG
;
Xiaomei LI
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Nephritis, interstitial;
Fibroblasts;
Monocytes;
T-lymphocytes
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Tubulointerstitial lesions, occurring in many kinds of renal diseases, have been found to be the predominant factor in the impairment of renal function. The severe and extensive lesions often predict a poor outcome in future. It has been tested recent years that the infiltrating inflammatory cells might play important roles in the onset and deterioration of tubulointerstitial injuries. On the other hand, the resident cells, including the tubular epithelial cells and the fibroblasts, also directly take part in tubulointerstitial inflammation and fibrosis. Researches also display implicated interactions between the infiltrating cells and the resident cells, which contribute to the amplification of inflammation and the progress of fibrosis.
