Suppression of Hematopoietic Stem /Pro genitor Cells by Sera from Patients with Systemic Lupus Erythe-matosus
- VernacularTitle:系统性红斑狼疮患者血清对正常造血干(祖)细胞的抑制作用
- Author:
Xiuzhen TONG
;
Shaokai LUO
;
Juan LI
;
Wende HONG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Pla sma;
IgG;
Hematopoietic stem cells;
Colony-forming units assay
- From:
Chinese Journal of Dermatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of hematolo gic abnormality in patients with systemic lupus erythematosus(SLE).Methods Suppression of granulocytic and ery throid colony formation of bone marrow cells fromhealthy individuals was examined in vitro by using methylcell ulose culture with sera or IgGdelete d sera from patients with SLE.Results①Both colony-forming units of erythr ocytes(CFU-E)(in 66.7%of samples tested)and granulocytes(CFU-GM)(in 70%of samples tested)of normal bone marrowcells were sign ificantly inhibited by sera frompatients with SLE(P
