Expression of Cyclooxygenase mRNA in Peripheral Blood Mononuclear Cells in Patients with Progressive Psoriasis
- VernacularTitle:寻常型银屑病患者外周血环氧合酶同工酶的研究
- Author:
Guoquan JIA
;
Xunquan LIU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Prostaglandin-endoperoxide synthase
- From:
Chinese Journal of Dermatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of constitutive cyclooxygenase(COX-1)and inducible cyclooxygenase(COX-2)in progressive plaque psoriasis and their clinical significance.Methods Re-verse transcription-polymerase ch ain reaction(RT -PCR)technique was applied to semi-quant itatively analyze COX-1and COX-2mRNA expression in peripheral blood mononuclear cells(PBMC)from 30psoriatic patients and 30healthy controls,and the correlation between COX-1/-2and psoria tic area and severity index(PASI )was evaluated.Results There was a significant difference o f COX-2mRNA expression level betwee n psoriatic pa-tients and normal controls(P0.05).Apositive correlation was noticed between COX-2and PASI (r=0.68,P
