Study on the Stability of Pilocarpine Nitrate Eye Drops by the Methods of Decision Design and Orthogonal Test
- VernacularTitle:正交与调优运算法对硝酸毛果芸香碱滴眼液稳定性的研究
- Author:
Yinghua ZOU
;
Jingjie CUI
- Publication Type:Journal Article
- Keywords:
pilocarpine nitrate eye drops;
orthogonal and decision design;
stability
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formula of pilocarpine nitrate eye drops by orthogonal test and decision design and to predict the stability of the preparation METHODS:The L9(33)orthogonal test method was used The test was performed according to the storage time and temperature,each of which took three levels to assess the stability and to choose the optimum formula to do the temperature accelerating test and estimate the stability by t0 9 methods RESULTS:The optimum point was pH4,temperature 8℃ and storage time 12 hours The storage period estimated by temperature accelerating test was 76 9 days CONCLUSION:It is simple,quick and accurate to predetermine the stability of pilocarpine nitrate eye drops by methods of orthogonal test and decision design
