Preparation and in Vitro Dissolution Characteristics of Famotidine Dispersible Tablets
- VernacularTitle:法莫替丁分散片的研制及体外溶出特性
- Author:
Jianchun ZHANG
;
Yuan WANG
;
Dingji CHEN
;
Chunhong WANG
;
Yaxu WEN
- Publication Type:Journal Article
- Keywords:
famotidine;
dispersible tablet;
orthogonal design;
dissolubility
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preparation of famotidine dispersible tablets and to observe the dissolution characteristics in vitro METHODS:To optimize the conditions for preparation by orthogonal design RESULTS:The tablets could completely disintegrate within 1 min;In vitro dissolution test showed T50=0 56min CONCLUSION:In comparison with commercial famotidine tablets,the dispersible tablets prepared in optimum condition were rapid in disintegration and homogenous in dispersal
