Clinical Observation of a Newly-developed Antiepileptic——Topiramate in Treatment of Epilepsy
- VernacularTitle:新型抗癫痫药托吡酯治疗癫痫的临床研究
- Author:
Songqing PAN
;
Dexing LIU
;
Shuangguo ZHANG
- Publication Type:Journal Article
- Keywords:
epilepsy;
topiramate;
therapeutic efficacy;
safety
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of topiramate in treatment of epilepsy METHODS:15 patients with refractory epilepsy treated with topiramate as additive drug and 61 newly-diagnosed epileptic patients with topiramate as monotherapeutic agent entered the open-label trial and were followed-up RESULTS:Among 15 patients with refractory epilepsy, the frequency of seizure decreased by 50% or greater in 10 cases with an effective rate of 66 7%, and 2 patients were free from seizure;among 61 newly-diagnosed cases, the frequency of seizure reduced by 50% or more in 45 cases(73 8%), and 16 cases were free from seizure(26 2%) The ARDs were lower in incidence and mild in severity CONCLUSION:Topiramate was safe and effective as additive or monotherapeutic agent for multiple types of seizure
