Effects of deoxynivalenol on apoptosis and proliferation of mouse thymocytes in vivo
- VernacularTitle:脱氧雪腐镰刀菌烯醇对小鼠胸腺细胞凋亡和增殖的影响
- Author:
Yuehong LI
;
Xianghong ZHANG
;
Junling WANG
;
Xia YAN
;
Xianghua HUANG
;
Jianzhu YANG
;
Yanli LIU
;
Fengrong WANG
- Publication Type:Journal Article
- Keywords:
Mice;
Thymus gland;
Apoptosis;
Hyperplasia
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of deoxynivalenol on apoptosis and proliferation of mouse thymocytes in vivo. METHODS: Effect of deoxynivalenol at different concentrations on apoptosis and proliferation of mouse thymocytes in vivo were studied with animal experiment, electron microscopic observation, DNA agarose gel electrophoresis and flow cytometric analyses. RESULTS: FCM analysis showed that the apoptosis rates of the thymocytes in DON groups (0 5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg and 8 mg/kg) were significantly higher than that in control ( P
