Effects of burn serum on the membrane of intestinal epithelial cell in rats
- VernacularTitle:烧伤血清对大鼠肠上皮细胞膜的影响
- Author:
Jun CHEN
;
Ao TANG
;
Shan CHANG
;
Guangxi XIAO
- Publication Type:Journal Article
- Keywords:
Burns;
Intestinal mucosa;
Membrane fluidity
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the mechanism and significance of the intestinal epithelial cellular membrane damage following burn serum. METHODS: The intestinal epithelial cell(IEC-6) were cultured. The changes of total membranous phospholipid contents fluidity of the IEC membrane were dynamically examined with fluorescence polarization technique and HPCE. RESULTS: In the early stage after stimulation by 20% burn serum, the membranous fluidity obviously decreased. The total phospholipid contents decreased, the content of PLA 2 markedly increased. CONCLUSION: The serial changes in IEC after burned could result in the damages of IEC membrane structure, the integrity of cell membrane and function.
