Effect of carbon monoxide on permeability of brain blood barrier in cerebral local ischemia rats
- VernacularTitle:CO对局灶性缺血脑组织血脑屏障通透性的影响
- Author:
Rong FU
;
Xiancheng CHEN
;
Huimin REN
;
Fusheng JIN
;
Houyan SONG
;
Yaodong JI
;
Jun REN
;
Yin XIA
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Carbon monoxide;
Heme oxygenase;
Blood-brain barrier;
Permeability
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the effect of carbon monoxide(CO) on the permeability of brain blood barrier(BBB) in cerebral ischemic rats. METHODS: SD rats were divided into three groups. Saline, hemin or ZnPP were injected intraperitoneally 12 h before middle cerebral artery occlusion (MCAO), respectively. The concentration of blood CO and the permeability of BBB at 24 h after MCAO were measured. RESULTS: The CO concentration in blood in hemin group was higher than that in saline group( P 0.05). CONCLUSION: CO reduced the permeability of BBB as a messenger gas molecular when its intrinsic concentration was elevated.
