Effect of polymorphonuclear leukocytes on washed platelet aggregation
- VernacularTitle:中性粒细胞对洗涤血小板聚集功能的影响
- Author:
Zhiqiang SHEN
;
Lanou WU
;
Li DUAN
;
Zhihe CHEN
;
Weiya LEI
;
Jika LIU
- Publication Type:Journal Article
- Keywords:
Blood platelets;
Neutrophils;
Platelet aggregation;
Aspirin
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of non-activated or activated polymorphonuclear leukocytes(PMN) on washed platelet aggregation. METHODS: Born's method was used to determine platelet aggregation.RESULTS: non-activated PMN (5?10 9 cells/L) significantly suppressed washed platelet aggregation induced by ADP or arachidonic acid. Aspirin enhanced this inhibition. N-formyl-methiongl-leucy-phenylalanine (fMLP)-or platelet-activating factor (PAF)-stimulated PMN strongly induced platelet aggregation, and the induction effect of PMN suspension was more active than that of PMN supernatant. Aspirin had no significant inhibitory effect on platelet aggregation induced by fMLP-or PAF-activated PMN. CONCLUSIONS: Different conditions of PMN (activated or non-activated) had the nearly opposite action on normal platelet reactivity. Briefly, non-activated-PMN inhibited platelet reactivity, whereas activated PMN stimulated it.
