Changes in calcium ion across plasma membrane by insulin related to the proliferation of human hepatocellular carcinoma
- VernacularTitle:胰岛素作用的跨膜钙离子流变化与人肝癌细胞增殖的关系
- Author:
Haiwei ZHANG
;
Yingru LUO
;
Peie ZHENG
;
Xiaoling CHEN
;
Turu SI
- Publication Type:Journal Article
- Keywords:
Hepatoma;
Insulin;
Calcium
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To examine the effect of insulin on the proliferation of human hepatocellular carcinoma cell and its possible mechanisms. METHODS: The human hepatocellular carcinoma cell line(HepG-2) was used to study the changes in calcium ion across plasma membrane (Ca 2+ APM)under the action of insulin by the assay of atomic absorption spectrum, and in the proliferation under the action of insulin and calcium ion antagonist (isoptin). RESULTS: The influx of Ca 2+ APM and the proliferation was increased after insulin administration, but the proliferation was inhibited by isoptin. CONCLUSION: Changes in the homeostasis of calcium ion across plasma membrane was involved in the effect of insulin on the proliferation of human hepatocellular carcinoma.
