Effect of ginsenoside Rh_2 on cultured PC-3M cells in vitro
- VernacularTitle:人参单体皂甙Rh_2对前列腺癌细胞株PC-3M细胞移行周期的影响
- Author:
Guihua ZHOU
;
Yan MENG
;
Yang LI
;
Xuejian ZHAO
;
Yanping CHEN
;
Xingyua MA
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Ginseng;
Cell cycle
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the influence of ginsenoside Rh 2 on cultured PC-3M cell cycle in vitro . METHODS: DNA content was measured using -TdR incorporation assay. To analysis the cycle changes of PC-3M cells, flow cytometry was used in the experiment.RESULTS: The results indicated that the rate of -TdR incorporation was lower in Rh 2-treated cells than the control in a dose-dependent manner. Flow cytometry demonstrated that the pecent of G 1 phase treated with Rh 2 was higher than that of control. CONCLUSION: These results suggested that PC-3M cells cultured with Rh 2 for 24 h were blocked at G 1 phase, and Rh 2 inhibited the growth of PC-3M cells in vitro .
