Association between apolipoprotein E polymorphism and lipid metabolism in patients with cerebral infarction
- VernacularTitle:载脂蛋白E多态性与脑梗死及脂类代谢关系的研究
- Author:
Yu XIA
;
Hongle LI
;
Jil WANG
- Publication Type:Journal Article
- Keywords:
Apolipoproteins E;
Polymorphism(genetics);
Phenotype;
Cerebral infarction;
Lipids;
Alleles
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the relationship between ApoE polymorphism and lipid metabolism of patients with cerebral infarction. METHODS: ApoE phenotype was determined in 110 patients with cerebral infarction and 60 normal controls by isoelectric focusing and immunoblotting. The TC, TG and HDL-C levels in serum of these subjects were measured with enzymes methods, ApoA I and ApoB levels with rocket immunoelectrophoresis methods, ApoE and Lp(a) levels with ELISA methods. RESULTS: The differences of the ApoE polymorphism distribution and ApoE allele frequencies ( P
