Effect of Aima recipe on the protein and mRNA expression of TNF? and ICAM-1 in the bronchus of rats with chronic bronchitis
- VernacularTitle:艾麻口服液对慢性支气管炎大鼠支气管TNF?、ICAM-1蛋白及mRNA表达的影响
- Author:
Guanghua TANG
;
Qifu HUANG
;
Liangdu JIANG
- Publication Type:Journal Article
- Keywords:
Lipopolysaccharides;
Bronchitis;
Chinese herbs;
Tumor necrosis factor;
RNA, messenger;
In situ hybridization;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of Aima recipe (AM), a traditional Chinese medicine, on the protein and mRNA expression of TNF? and ICAM-1 in the bronchus of rats with chronic bronchitis(CB). METHODS: 15 male Wistar rats were randomly divided into three groups: control group, chronic bronchitis (CB) group, CB plus AM group. The protein and mRNA expression of TNF? and ICAM-1 were assayed by immunohistochemistry and in situ hybridization methods. RESULTS: TNF?, ICAM-1 protein and mRNA were more strongly expressed in the area of bronchial epithelium in the CB group compared with control group ( P
